D-mannose is a simple sugar found naturally in many fruits. It is best known for its effectiveness in preventing and clearing urinary tract infections. D-mannose works by attaching to E. coli bacteria (Escherichia coli), which is the main pathogen that causes these infections. E. coli bacteria tend to attach to the bladder walls with their fimbriae, but D-mannose binds to these fimbriae, forming a complex that is then flushed out of the body during urination. Through this mechanism, D-mannose effectively prevents E. coli bacteria from colonizing the urinary tract, reducing the risk of infection. Unlike antibiotics, D-mannose does not disrupt the natural gut flora, making it safe for long-term use and not contributing to the development of antibiotic resistance. Studies show that regular use of D-mannose protects against recurrent infections with similar efficacy to antibiotics⁵.

Cranberry fruit extract containing up to 10% proanthocyanidins, the ingredient responsible for the beneficial effects on urinary tract health. Proanthocyanidins (PACs) are potent bioactive compounds that make it difficult for bacteria to adhere to the walls of the bladder and urinary tract, preventing colonization and the development of urinary tract infections^8,9. The effect of proanthocyanidins is mainly to prevent pathogenic bacteria from adhering to epithelial cell walls, while at the same time not affecting healthy bacteria such as Lactobacillus. This allows for a selective anti-adhesion effect targeting only pathogenic bacteria, while maintaining the integrity and balance of healthy probiotic strains present in the urinary and gastrointestinal tracts.

Green tea leaf extract standardized to 40% EGCG (epigallocatechin gallate) has many benefits for the urinary tract, especially in the prevention and clearance of urinary tract infections. EGCG has strong antimicrobial properties that help inhibit the growth of bacteria such as Escherichia coli, which is responsible for most urinary tract infections¹⁰. EGCG also supports detoxification of the body by stimulating kidney function, helping to eliminate toxins and excess fluids, which positively affects urinary tract health. In addition, its anti-inflammatory properties can reduce inflammation in the body, which supports tissue health and improves overall well-being.

Dandelion has a wide range of uses, especially in the context of supporting urinary health and detoxifying the body. It contributes to the proper functioning of the kidneys and bladder. Its diuretic action helps remove excess fluid from the body, supporting kidney health and reducing water retention. As a result, it also aids in the elimination of toxins, which improves overall urinary function. Dandelion also contains antioxidants that protect cells from damage caused by oxidative stress, supporting health at the cellular level. In addition, dandelion extract has anti-inflammatory properties that can help reduce inflammation, including in the urinary tract, which is beneficial for those who suffer from recurrent infections¹¹.

Rosehip extract is an excellent source of natural and highly bioavailable vitamin C, making it one of the richest sources of vitamin C and a powerful antioxidant that helps protect the body from oxidative stress and free radicals. In addition, it supports the proper functioning of the kidneys and bladder and has mild diuretic properties, thus supporting the body's detoxification and kidney health by helping to eliminate excess fluids and toxins.

Nettle leaf extract standardized to 4% polyphenols supports urinary health in several ways. First, it has a diuretic effect, which helps increase urine output and supports kidney and bladder health. By removing excess fluid, the extract helps to eliminate toxins and reduce the risk of urinary tract infections. In addition, the polyphenols in nettle have anti-inflammatory properties that promote the reduction of inflammation in the urinary tract, helping to prevent bladder infections. Nettle extract is also helpful in relieving symptoms associated with benign prostatic hyperplasia in men¹², which can promote better urine flow and reduce the frequency of nighttime urination. Thanks to its antibacterial and antioxidant properties, nettle supports the health of the entire urinary tract, protecting it from free radical damage.

Vitamin D supports the immune system in the fight against infections, including urinary tract infections. It works by boosting the body's immune response, which helps it fight the bacteria responsible for infections more effectively. Studies suggest that people with low levels of vitamin D may be more susceptible to recurrent urinary tract infections because the vitamin affects the production of antibacterial peptides, such as cathelicidins, which help eliminate bacteria from the urinary tract¹³. Vitamin D also helps regulate calcium and phosphorus levels, which are important for proper kidney function and the prevention of kidney stone formation.